Fig. 6: DE analysis reveals distinct gene expression patterns between TrkB.T1 High vs TrkB.T1 Low GSC lines. | Nature Communications

Fig. 6: DE analysis reveals distinct gene expression patterns between TrkB.T1 High vs TrkB.T1 Low GSC lines.

From: A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways

Fig. 6

a Schematic for differential gene expression analysis between TrkB.T1 High (classical/proneural replicates 448 1–3; classical/mesenchymal G14 replicates 1–3) and TrkB.T1 Low (classical/proneural replicates 559 replicates 1–3; classical/mesenchymal G179 replicates 1–3). b PCA plots show distinct clusters for the TrkB.T1 High GSC line (488) compared with the TrkB.T1 Low GSC (559) line in the classical/proneural lines and distinct and (c) for the TrkB.T1 High GSC Line (G14) compared with the TrkB.T1 Low GSC line (559). GO analysis revealed distinct genesets downregulated in the cellular compartment (d) and distinct genesets downregulated in biological processes (e) in the TrkB.T1 High (448 and G14) line compared with the TrkB.T1 Low (559 and G179) lines. TrkB.T1 Low lines (559 and G179) shown in green and TrkB.T1 High lines (448 and G14) shown in purple.

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