Fig. 5: MNV-1 replicates in intestinal subepithelial cells and splenocytes.
From: Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal mice
Tissue sections from mock-inoculated or MNV-1-infected mice collected at 1 dpi (a, b; n = 5 per group) and 2 dpi (c–e; n = 7 per group) were probed for viral positive-sense and negative-sense RNA. Representative images of gut-associated lymphoid tissue (GALT), intestinal villi, and splenic tissue are shown for 1 dpi (a) and at 2 dpi for 2 distinct patterns (c, d). The amount of positive-sense (black) and negative-sense (red) viral RNA detected was scored for each pup, as described in the “Methods” at 1 dpi (b) and 2 dpi (e). Scale bars represent 50 µm for all images except for insets where they represent 10 µm. Error bars denote standard errors of mean in all figures. Source data are provided as a Source data file.
