Table 1 Postnatal lethality in MlklD139V/D139V homozygotes is independent of Tnfr1, Myd88, Ripk3, Casp8, Casp1, and Casp11.

From: A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Stage genotyped

E14

E18

P21

P21

P21

P21

P21

P21

P21

C57BL/6 genetic background

Wt

Wt

Wt

Tnfr1−/−

Myd88−/−

Ripk3−/−, C8+/−

Ripk3−/−, C8−/−

Ifnar−/−

C1−/−, C11−/−

MlklWt/Wt

58 (39)

7 (9)

15 (11)

19 (15)

3 (2)

10 (6)

2 (2)

15 (11)

10 (8)

MlklWt/D139V

70 (78)

17 (18)

30 (22)

41 (30)

6 (4)

14 (12)

5 (4)

30 (22)

21 (16)

MlklD139V/D139V

28 (39)

13 (9)

0 (11)

0 (15)

0 (2)

0 (6)

0 (2)

0 (11)

0 (8)

Total # genotyped

156

37

45

60

9

24

7

45

31

  1. () - number of pups expected from Mendelian segregation, calculated from total number of pups genotyped and rounded to the nearest whole number. Gene names italicized.
  2. E, embryonic day; P, days postnatal.
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