Fig. 3: CCL20-bound CCR6 is in the active state.
From: Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20
a Structural superposition of CCR6 7TM (light magenta) with CCR7 (green) and CCR9 (white) from the orthogonal, extracellular, and intracellular views. Conformations of the D3.49R3.50Y3.51 and N7.49P7.50xxY7.53 motifs in the active CCR6 and the inactive CCR7 and CCR9 structures are highlighted in the insert. Parts of TM5 and TM6 have been removed for clarity. b Conformation of the conserved side-chains Y3.32, N6.52 and Q6.48 of CCR9, CCR7, and CCR6. c Conformation of the P5.50M3.40F6.44 motif in inactive CCR7 (green) and active CCR6 (light magenta), and comparison with the conformation of the P5.50I3.40F6.44 motif in the inactive (2RH1, yellow orange) and active β2AR (3SN6, deep blue).
