Fig. 5: Diverse conformations adopted by ICL2 for G protein coupling.
From: Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20
a Structural alignment of GPCR–G protein complexes demonstrates ICL2 of CCR6 (light magenta) adopts a unique conformation when coupled to G proteins. Structures used for comparison are: NTS1R–Gi (6OS9, wheat), μOR-Gi (6DDE, pale yellow), M1-G11 (6OIJ, orange), Rhodopsin-Gi (6QNO, purple), and β2AR-Gs (3SN6, deep blue). b Interactions between ICL2 and the Gα subunit in different GPCR–G protein complexes represented as in (a), with only receptor side-chains labeled for clarity. Gα proteins are colored in green for clarity.
