Fig. 4: Active DENV infection induces inflammatory mediators in a TLR2-dependent manner. | Nature Communications

Fig. 4: Active DENV infection induces inflammatory mediators in a TLR2-dependent manner.

From: TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis

Fig. 4

a HUVEC were incubated for 6 h with cell-free supernatants from PBMCs infected in the presence or absence of TLR2 blockade. b Boxplots show the fold-changes in surface expression of E-selectin, VCAM-1 and ICAM-1 compared to the respective mock (n = 4, paired one-tailed t test, *P < 0.05; **P < 0.01). The horizontal line represents the median and the whiskers the minimum and maximum values. c Fold-changes in gene expression levels of E-selectin, VCAM-1, and ICAM-1 relative to the respective mock (n = 2). d Fold-changes in gene expression levels of IL-6, IL-8, MCP-1, and CXCL6 relative to the respective mock (n = 2). N refers to the number of independent biological experiments in HUVEC. Source data are provided as a Source data file.

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