Fig. 5: TLR2/CD14-dependent cytokines induced by DENV2 infection. | Nature Communications

Fig. 5: TLR2/CD14-dependent cytokines induced by DENV2 infection.

From: TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis

Fig. 5

PBMCs from healthy donors were (mock)—treated with αTLR2, αTLR1, αTLR6 (5 µg/mL) and αCD14 (3 µg/mL) for 2 h prior to infection with DENV2 at MOI of 20 for 48 h (n = 2, two different donors and 3 different DENV2 preparations, one-way ANOVA, Dunnett post hoc test, **P < 0.01). Cytokine production was measured by flow cytometry using LegendPlex. Each boxplot in the graphs shows the production in picograms per milliliter (pg/mL) of the respective cytokine. The horizontal line represents the mean and the bottom and top of the box show the minimum and the maximum values. Source data are provided as a Source data file.

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