Fig. 2: Absence of de novo methylation in DKO embryos. | Nature Communications

Fig. 2: Absence of de novo methylation in DKO embryos.

From: Genome-wide analysis in the mouse embryo reveals the importance of DNA methylation for transcription integrity

Fig. 2

a Genome browser tracks of WGBS methylation profiles in gametes, early embryos31, and E8.5 Dnmt mutant embryos, highlighting the strong similarity of methylation patterns between the ICM (Inner Cell Mass) and DKO embryos. CpG islands (CGIs) depicted by green rectangles and RefSeq gene annotations are shown below the tracks. b Density scatter plot of WGBS methylation scores in 1 kb windows in E8.5 DKO embryos compared with E3.5 ICM. The density of points increases from blue to dark red. c Boxplots of the CG methylation levels in ICM, postimplantation embryos, and E8.5 DKO embryos for all genomic windows de novo methylated at implantation, illustrating that de novo methylation is abolished in DKO embryos. In the boxplots the line indicates the median, the box limits indicate the upper and lower quartiles and the whiskers extend to 1.5 IQR from the quartiles.

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