Fig. 3: Real-time NIR-II imaging of the ischemic reperfusion in hindlimbs.
From: Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging
a Schematic illustration of the ischemic reperfusion process. b NIR-II bioimaging with LZ-1105 administration of ischemic reperfusion at different time points after various period clipping treatment (1400 nm long-pass, λex = 1064 nm, 300 ms) as indicated. Three regions of interest (ROI) named as the front, middle, and end sites as shown with yellow circles were chosen to evaluate the ischemic reperfusion process. Yellow arrows indicate the flow front. c The corresponding distance traveled by the flow front at the front, middle, and end site as a function of time after 1, 4, 8, and 12 h clipping, respectively. The slope of the function was calculated as blood flow velocity (BFV) and indicats mean ± s.d. derived from n = 3 replicated measurements. Scale bar represents 4 mm. Source data underlying c is provided as a Source Data file.
