Fig. 4: Real-time NIR-II imaging of the thrombolysis process in carotid artery.
From: Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging
a Schematic illustration of the thrombolysis process. Inset: Ultrasonic imaging of carotid artery without (left) and with (right) thrombus, demonstrating successful formation of a thrombus in the right carotid artery (n = 3 mice). b NIR-II bioimaging of the carotid artery performed by LZ-1105 at various time points p.i. of recombinant tissue plasminogen activator (rt-PA) administration (1400 nm long-pass, λex = 1064 nm, 300 ms). The red dashed and yellow solid arrows indicate the blood flow direction and signal front, respectively. c Recovered blood flux during thrombolysis process as a function of time. The slope of the function was calculated as the recovered blood flux rate in thrombolysis and indicats mean ± s.d. derived from n = 3 replicated measurements. Scale bar represents 3 mm. Source data underlying c is provided as a Source Data file.
