Fig. 2: 10–1074 antibody concentration predicts the probability of infection following penile SHIVSF162P3 challenge. | Nature Communications

Fig. 2: 10–1074 antibody concentration predicts the probability of infection following penile SHIVSF162P3 challenge.

From: Durable protection against repeated penile exposures to simian-human immunodeficiency virus by broadly neutralizing antibodies

Fig. 2: 10–1074 antibody concentration predicts the probability of infection following penile SHIVSF162P3 challenge.

a Probit regression analysis was used to estimate the per-challenge probability of penile SHIV acquisition as a function of imputed 10–1074 concentration in plasma. The per-challenge probability of infection among untreated control animals was 0.25 (95% CI 0.13–0.41) and is denoted in blue. Tick marks represent SHIV challenge events that either did (red) or did not (green) result in systemic infection. The solid black line is the model-based prediction; dotted black lines depict 90% pointwise confidence intervals. b Model-based estimates of SHIV infection probabilities following a single penile challenge and reduction of infection probability as compared with controls, at the indicated plasma concentrations of 10–1074.

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