Fig. 7: Notch1 stimulates BRCA1-related TNBC progression by promoting EMT.
From: NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation
a Gene expression analysis of Notch1-driven TNBC SB tumours (n = 24) compared with non-Notch1-driven TNBC SB tumours (n = 4). b GSEA analysis reveals that upregulated genes in Notch1-driven tumours are enriched in the EMT_breast_tumour_up term. c GSEA analysis indicates that downregulated genes in Notch1-driven tumours are enriched in the EMT_breast_tumour_dn term. d Western blotting analysis of EMT markers after induction of ICN1 in MCF10A and MCF10A-BRCA1-knockdown cells. e Western blotting analysis of EMT markers after induction of ICN1 in T47D and T47D-BRCA1-knockdown cells. f Meta-analysis of BRCA1-mutant human breast tumours for EMT markers, basal markers, luminal markers and TNBC markers.
