Fig. 2: Binding of arenicin-3 variants to lipids as monitored by SPR.
From: An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria
Comparison of the propensity of arenicin-3, AA139, NZ17143, NZ17211, and other membrane binding antimicrobials, colistin and polymyxin B, to bind to various model membrane lipid systems. DMPC (gray) is compared to DMPC with 10% E. coli lipid A (white) at 1 µM a and 10 µM b. Mean data of n = 3 per test group is plotted with error bars shown as SEM. Significant difference in binding affinities can be seen for colistin and polymyxin B between the two lipid systems; however, not for arenicin-3 variants. Statistical comparison performed with Prism 8 using Student’s t-test, all differences between means with p < 0.01 are indicated; ***p ≤ 0.001. RU response unit, MW molecular weight. Source data are provided as a source data file.
