Fig. 1: Directed acyclic graphs of potential Mendelian randomisation pathways.
From: Genetic drug target validation using Mendelian randomisation
Nodes are presented in bold face, with G representing a genetic variant, P a protein drug target, X a biomarker, D the outcome, and U (potentially unmeasured) common causes of both P, X, D. Labelled paths represent the (causal) effects between nodes.
