Fig. 1: MCJ deficient mice are resistant to develop liver steatosis and fibrosis in the MCD diet model. | Nature Communications

Fig. 1: MCJ deficient mice are resistant to develop liver steatosis and fibrosis in the MCD diet model.

From: Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation

Fig. 1

(a–d) WT (n = 5) and MCJ KO (n = 5) mice were placed on MCD (methionine- and choline-deficient) diet for 2 weeks prior to liver harvest. a Representative liver H&E images from WT and MCJ KO mice. b Representative images and (c) quantitation of liver lipid content determined by Sudan III staining and shown as percentage of the total histological area. (d) Serum AST levels. e, f WT (n = 5) and MCJ KO (n = 5) mice were placed on MCD diet for 3 weeks prior to liver harvest. e Representative images and (f) quantification of liver fibrosis determined by Picro Sirius Red staining and shown as the number of fibrotic areas per histological section. *denotes p < 0.05 as determined by Student´s t test. Error bars show standard error (SE) in (c) and (d), and standard deviation (SD) in (f). Source data are provided as a Source Data file.

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