Fig. 1: Schematic of signal transduction and nonlinear odor mixture interactions in OSNs.
From: Antagonistic odor interactions in olfactory sensory neurons are widespread in freely breathing mice
a Schematic of sensory transduction in OSNs. Odors generate responses in OSNs with different levels of efficacy. Olfactory receptor (OR), adenylyl cyclase (AC), cyclic nucleotide gated channel (CNG), calmodulin (CaM), calcium-activated-chloride channel (CaCC). b Mixtures of odors can give rise to nonlinear responses in OSNs. Three solid purple lines show hypothetical mixture suppression (antagonism) at varying levels with respect to the component-based linear prediction (dashed purple). c Although less common, mixture responses can also display synergy where the mixture response exceeds the component-based linear prediction.
