Fig. 1: NMD targets and canonical histone mRNAs accumulate in c9ALS brains.
From: C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression
a Histograms showing changes in intron read densities between c9ALS and controls (red), or between sALS and controls (blue). P values, one-sided Mann–Whitney U tests. b Cumulative distribution functions (CDFs) of changes in RNA abundance for all genes (black), NMD targets identified in Johnson et al. (N = 275, red), Tani et al. (N = 76, orange), and in Colombo et al. (N = 1271, yellow), comparing between c9ALS and controls (left) or sALS and controls (right). P values, two-sided Mann–Whitney U tests. c Changes in mRNA abundance of known NMD factors between c9ALS and controls. Expression levels were normalized to the means of control subjects. Boxes indicate the medians and interquartile ranges (IQRs). Whiskers represent 1.5x IQR. P values, two-sided unpaired t tests. d CDFs of changes in RNA abundance for all genes (black) and canonical histone genes (N = 87, red and blue), comparing between c9ALS and controls (left) or sALS and controls (right). P values, two-sided Mann–Whitney U tests.
