Fig. 6: Evolutionary conserved helices C-terminal to the AIM/LIR enhance interactions between ER-phagy receptors and Atg8-family proteins. | Nature Communications

Fig. 6: Evolutionary conserved helices C-terminal to the AIM/LIR enhance interactions between ER-phagy receptors and Atg8-family proteins.

From: Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes

Fig. 6: Evolutionary conserved helices C-terminal to the AIM/LIR enhance interactions between ER-phagy receptors and Atg8-family proteins.The alternative text for this image may have been generated using AI.

a, b Crystal structures of GABARAP-FAM134B450–468, GABARAP-SEC62361–376, and RTN3245–264. Green and pink indicate GABARAP and ER-phagy receptor AIMs, respectively. c Superimposition of Atg8/GABARAP-binding regions of ER-phagy receptors based on the structures of Atg8 and GABARAP. d, e Binding affinity of FAM134B (d) and SEC62 (e) peptides to GABARAP was measured by ITC.

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