Fig. 4: Regulatory ERVs modulate host gene expression. | Nature Communications

Fig. 4: Regulatory ERVs modulate host gene expression.

From: Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia

Fig. 4: Regulatory ERVs modulate host gene expression.

a Genome browser view of three candidate ERVs, showing H3K27ac and TF ChIP-seq tracks in K562 cells. b–d Expression of nearby genes (left) in the excision clones of the indicated ERVs. Bars represent mean values. Data points are from multiple samples (collected every 2–4 days) from each independently derived clone, as follows: four samples from 2+/+, 3+/− and 1−/− clones (b), 3 samples from 3+/+ and 3+/− clones (c), and 8 samples from 2+/+, 3+/− and 1−/− clones (d). P values are from one-way ANOVA with Tukey′s multiple-comparison test (b, d) or two-tailed t test (c). Expression of the indicated ERV vicinity genes (right) in HSC (n = 6), monocyte (n = 8), macrophage (n = 6), and AML (n = 27) samples (boxes indicate first, second (median) and third quartiles; whiskers indicate data within 1.5× of the interquartile range). Source data are provided as a Source Data file for (b–d).

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