Fig. 4: Homogeneous bivalent marking of histone H3 on sperm developmental genes. | Nature Communications

Fig. 4: Homogeneous bivalent marking of histone H3 on sperm developmental genes.

From: Epigenetic homogeneity in histone methylation underlies sperm programming for embryonic transcription

Fig. 4

a Fold enrichment (observed/random) over 1000 randomisations of peaks with homogeneous H3K4 methylation (HMD > 80) in regions homogeneous for nucleosomes, homogeneous for subnucleosomes or with heterogeneous particle composition in a sperm population; ***: empirical p value < 1e−3. b Same as in a for H3K27 methylation. c PAM clustering of promoter (TSS +/−2 kb) according to homogeneity for methylation of histone H3 (HMD > 80) on Lysine 4, on Lysine 27, enrichment for nucleosomes and enrichment for subnucleosomes. Source data related to c is provided as a Source Data file. ICe-ChIP data from two independent replicates were pooled.

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