Fig. 7: Assessment of the effects of surface passivation in mouse lungs.
From: Vacancies on 2D transition metal dichalcogenides elicit ferroptotic cell death
a Neutrophil counts in BALF. Animals were exposed to 1 mg/Kg pristine or surface modified TMDs by oropharyngeal aspiration (n = 6 mice). After 40 h, the animals were sacrificed and alveolar macrophages in BALF of mouse lungs were collected for overnight incubation. Immune cells in BALF were concentrated on glass slides by cytospin, fixed and stained by Quick-Diff for cell counting. Neutrophil count data are presented as mean values ± SD. b Pro-inflammatory cytokine production in BALF and c representative H&E staining images of lung tissues from six biologically independent samples (scale bar: 100 μm). Pro-inflammatory cytokines were determined by ELISA. Cytokine data are presented as mean values ± SD. *p < 0.05, **p < 0.01, ***p < 0.001 compared to vehicle controls, #p < 0.05, ##p < 0.01, ###p < 0.001 compared to WS2 and MoS2 by two-tailored Student t-test.
