Fig. 3: RNA-protein interactions in RNase MRP. | Nature Communications

Fig. 3: RNA-protein interactions in RNase MRP.

From: Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP

Fig. 3: RNA-protein interactions in RNase MRP.The alternative text for this image may have been generated using AI.

a The structure of the conserved element 5′-GA(G/A)A(G/A)-3′ (nucleotides 109–113) and its interactions with protein Pop1 (red). The 5′-GA(G/A)A(G/A)-3′ element folds into a GNRA tetraloop capping stem P8, with the last purine (A113) bulging out. A113 is observed in both syn- and anti- conformations; the syn- conformation appears to be stabilized by a stacking interaction with the conserved Arg107 of protein Pop1. b–e Loop L5 of the S-domain caps the P5 stem. The loop is devoid of the base pairs; its structure is stabilized by interactions with protein components Pop4 (green) and Snm1 (blue).

Back to article page