Fig. 5: Analysis of PP1c/PP2Ac-affected p-sites. | Nature Communications

Fig. 5: Analysis of PP1c/PP2Ac-affected p-sites.

From: Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A

Fig. 5

The data are from the phosphoproteomic experiments (Supplementary Data 2; Supplementary Fig. 4b, c). a Motif analysis of PP1c/PP2Ac (in)sensitive class I sites. Color of single letter code represents biochemical properties with red = basic, purple = acidic. The enrichment of R in PP1c-sensitive p-sites over PP2Ac-sensitive sites was tested by a two-sided Fisher’s exact test and was found to be statistically different (p-value 0.019). Source data are provided as a Source Data file. b Hierarchical clustering of p-sites after one-way ANOVA analysis using Perseus software. Color scale represents log2-fold change after z-transformation. The three largest clusters are depicted in detail on the right. Each line corresponds to one p-site. These data are also the basis for PP1c/PP2Ac-specific sites presented in Table 1.

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