Fig. 2: Structural and conformational changes of SARS-CoV S glycoprotein from pre-fusion to post-fusion state.
From: Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein
a Topology and cartoon representation of SARS-CoV S2 subunit in pre-fusion state20 (PDB: 6NB6) colored as in Fig. 1a. The S1 subunit in the pre-fusion state is colored white. b Topology and cartoon representation of SARS-CoV S2 subunit in post-fusion state colored as in Fig. 1a. Unobserved regions in the structures are colored in light gray or presented as dashed lines in the topology diagram of (a, b). c Structural transition of the HR1 and CH motifs during membrane fusion. d Structural changes of the UH, BH, and SD3 during membrane fusion.
