Fig. 1: Pedigrees and clinical manifestations of familial carpal tunnel syndrome (CTS).
From: Mutations in COMP cause familial carpal tunnel syndrome
a Two pedigrees of familial carpal tunnel syndrome. The pedigree diagram of Family 1 is simplified, also see Supplementary Fig. 1 for the full pedigree diagram. Squares and circles denote male and female family members, respectively. Solid and open symbols denote affected and unaffected family members, respectively. The individuals with numbers underneath indicate the family members recruited in this study. The arrows indicate the probands; Family 2 has two probands who were identified in a single search of hospital records. b Magnetic resonance imaging (MRI) results indicate enlarged digital flexor tendons and compressed median nerves in patients’ carpal tunnels (two-tailed t test, ***p = 2.98 × 10−5 (Family 1) and 2.07 × 10−7 (Family 2) for area ratio of flexor tendon/carpal tunnel; ***p = 6.21 × 10−6 (Family 1) and 8.94 × 10−5 (Family 2) for median nerve, error bars are ± SEM). c MRI results indicate thickened transverse carpal ligaments (TCLs) in patients’ carpal tunnels (two-tailed t test, ***p = 7.90 × 10−5 for Family 1 and *p = 0.011 for Family 2, error bars are ± SEM). The hook of the hamate bone was used as a reference position, and the thickness of the TCLs was measured at the carpometacarpal level. n = 13 in controls, n = 11 in Family 1, and n = 7 in Family 2. Source data are provided as a Source Data file.
