Fig. 2: Histological analysis of CTS patients’ biopsies.
From: Mutations in COMP cause familial carpal tunnel syndrome
Transverse carpal ligament (TCL) tissues collected from controls (n = 2) and Family 1 patients (n = 3) were analyzed. a H&E staining reveals collagen fragmentation, edema (asterisk), and vascular structures (arrows) in patients. b–d Immunostainings indicate lipomatosis (perilipin) and fibrosis (α-SMA and type III collagen) in patients’ TCLs. e Transmission electron microscopy (TEM) reveals a number of ectopic small fibrils and contrast difference in patients’ extracellular matrix (ECM). Source data are provided as a Source Data file.
