Fig. 6: Timeline of mutational signatures.
From: Accelerated single cell seeding in relapsed multiple myeloma
a Mutational signature contribution for each phylogenetic tree cluster for each sample. Asterisks indicate the presence of transcriptional strand bias for SBS-MM1. Red and green dashed arrows represent exposure to melphalan and platinum-based therapies, respectively. L = left; R = right. B-cc) A schema summarizing the relationship between chemotherapy, subclonal selection and seeding in (b) I-H-106917 and (c) I-H-130718. (HDM = high-dose melphalan, PACE = cisplatin, doxorubicin, cyclophosphamide and etoposide, SBS = single base substitution). Red and green dashed lines in (b) and (c) represent exposure to melphalan and platinum-based therapies, respectively.
