Fig. 5: Persistence of innate immunity dysfunction in EBOV_S.
From: Long-lasting severe immune dysfunction in Ebola virus disease survivors
Unsupervised principal component analysis of serum-soluble mediators and cell phenotypic data, including n = 26 EBOV_S and n = 33 HDs. EBOV_S are indicated in red and HDs in blue (a). Variables used for the construction of the components (b). Spearman’s correlation matrix between serum-soluble mediators and cell phenotypes from n = 39 HDs and n = 34 EBOV_S. Colors indicated Spearman’s correlation coefficient. Only significant correlations (p < 0.05) are represented (unadjusted for test multiplicity) (c). Unsupervised PCA including genes (blue) from the main pathways associated with differentially expressed genes in EBOV_S and HDs, including IFN signaling, the complement system and PRR signaling pathways (d).
