Fig. 6: A hydrophobic spine connects input effector-sensing to output DNA-binding. | Nature Communications

Fig. 6: A hydrophobic spine connects input effector-sensing to output DNA-binding.

From: Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine

Fig. 6

a Hydrophobic-spine amino acids in FasR. The colour code depicts residues of the DNA-binding domain in orange, the effector-binding domain in grey and the α6–α7 loop in cyan. b–d distinct TFRs (FasR, RutR, RamR) illustrate the conservation of the hydrophobic spine (residues shown as molecular surface), connecting effector- to DNA-binding domains. The colour code is identical to panel a. The effector molecules in atom-coloured sticks are labelled, with transparent spheres overlaid (insets show their markedly disparate structures). See Supplementary Fig. 13 for additional examples.

Back to article page