Fig. 7: FasR-mediated long acyl-CoA sensing and response mechanism. | Nature Communications

Fig. 7: FasR-mediated long acyl-CoA sensing and response mechanism.

From: Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine

Fig. 7

The model combines information from the three crystal structures presented in this report (FasRΔ33-C14, FasRΔ33-C20-CoA and FasR–DNA complexes). A free structure of FasR with no bound effectors nor DNA has not been determined experimentally, and is not currently known whether it builds up to detectable concentrations within the living cell. The dotted arrows reflect plausible equilibria. See Supplementary Movie 3 to better grasp the anticipated dynamics.

Back to article page