Fig. 5: Compound 2a attenuates sciatic nerve degeneration in G93A mice.
From: Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis
a Low and high magnifications of a sciatic nerve cross section from a vehicle-treated WT mouse. b Low and high magnifications of a sciatic nerve cross section from a vehicle-treated G93A mouse. c Low and high magnifications of a sciatic nerve cross section from a compound 2a (10 mg/kg)-treated G93A mouse (day 100). Quantifications (means + SD) of degenerating fibers/mm2 scored in the entire cross section of nerves are shown in d, and data are examined over two independent experiments (WT n = 7 independent mice, G93A-vehicle n = 8 independent mice, G93A-compound 2a n = 9 independent mice).(G93A-v vs. G93A-2a: p = 0.02. One-way ANOVA followed by Tukey's Multiple Comparison test was used to analyze data. *p < 0.05. Scale bars 50 µm for low-magnification images and 20 µm for high-magnification images.
