Fig. 2: Bifurcated ligand-binding pocket in the ghrelin receptor, and the structure of the gap.
From: Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode
a The cutaway surface for the ghrelin receptor in complex with the antagonist Compound 21 reveals a bifurcated ligand-binding pocket. b The ligand-binding pocket of the ghrelin receptor. c Schematic model of Fig. 2b. d The phenylalanine cluster forms a crevasse in the ghrelin receptor. The five phenylalanines are shown as sticks in dark orange. The crevasse is shown as a red dashed line. G282 is shown as spheres with carbon atoms in orange, nitrogen in blue, and oxygen in red.
