Fig. 5: Comparison of ligand–binding modes of the ghrelin receptor, S1P1 receptor, and CB1 receptor. | Nature Communications

Fig. 5: Comparison of ligand–binding modes of the ghrelin receptor, S1P1 receptor, and CB1 receptor.

From: Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode

Fig. 5: Comparison of ligand–binding modes of the ghrelin receptor, S1P1 receptor, and CB1 receptor.

The ghrelin receptor surface and its cross-section were colored according to electrostatic potential from red (negative) to blue (positive) using APBS tools. a The S1P1 receptor (PDB ID: 3V2Y) and (b) the CB1 receptor (PDB ID: 5XRA) are superposed onto the ghrelin receptor. The 2796.51, F3097.39, and F3127.42 of the ghrelin receptor and Compound 21 are depicted as orange and yellow sticks, respectively. The sphingolipid mimic S1P1 antagonist (ML056) and the CB1 antagonist (AM11542) are depicted as pink and cyan sticks, respectively.

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