Fig. 1: Discovery study design for the SCAD genome-wide association analysis (GWAS) and PRSSCAD development and testing. | Nature Communications

Fig. 1: Discovery study design for the SCAD genome-wide association analysis (GWAS) and PRSSCAD development and testing.

From: Chromosome 1q21.2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarction

Fig. 1: Discovery study design for the SCAD genome-wide association analysis (GWAS) and PRSSCAD development and testing.

In both the discovery and replication phases, CanSCAD study samples were analyzed with control subjects derived from the MGI biorepository with electronic health record-based phenotyping to exclude individuals with vascular diseases or connective tissue disorders. The association of genetic variants with SCAD and MI was tested by means of a PRS developed with the top ranked loci in the GWAS meta-analysis of SCAD discovery and replication analyses (PRSSCAD). The PRSSCAD was tested for association with SCAD and MI in a cohort of individuals with FMD and for CAD and MI in the UK Biobank and MVP.

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