Fig. 5: PheWAS phenotypic associations in the UK Biobank.
a PheWAS of the PRSSCAD vs. self-reported non-cancer medical illnesses in the UK Biobank (n = 373,015). The different color dots represent the association results (logistic regression two-sided test P values in minus log base ten scale) of the PRSSCAD for non-cancer illness categories. Two-sided P values were considered significant when below a Bonferroni-adjusted threshold (0.05/2356 ≈ 2.12 × 10−5). b Sex-specific ORs in blue circles for males (n = 171,082) or purple circles for females (n = 201,974) are shown in the center of the corresponding 95% confidence interval (CI) from the PRSSCAD analysis for migraine headache and MI, with two-sided values of P values displayed. Events in the legend denote the number of migraine cases or MI cases among the female or male groups, with N shown for the total sample size for each group. The models were adjusted for age at enrollment, genetic sex, genotyping array and batch, and the first four PCs. The logistic regression Wald statistic of two-sided P values are displayed.
