Table 1 Fifteen novel methylation-prostate cancer associations for CpG sites located at genomic loci at least 500 kb away from any known prostate cancer risk varianta.

From: An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk

CpG site

Chr

Position (build37)

Classification

R2b

OR (95% CI)c

P valued

risk SNP

Distance to the risk SNP (kb)

P value after adjusting for risk SNPe

cg18800143

1

16393791

Intronic

0.10

1.12 (1.07–1.17)

7.56 × 10−8

rs636291

5837.7

7.07 × 10−9

cg07645299

2

63991864

Intergenic

0.01

1.49 (1.30–1.71)

1.58 × 10−8

rs58235267

714.0

0.80

cg12627844

2

64245000

Intronic

0.03

1.38 (1.28–1.50)

1.98 × 10−15

rs58235267

967.2

0.61

cg16397176

5

110899314

ncRNA_intronic

0.05

1.15 (1.09–1.22)

6.42 × 10−7

rs10793821

22936.9

6.25 × 10−7

cg11562153

6

28493500

Upstream

0.04

1.22 (1.13–1.31)

1.57 × 10−7

rs7767188

1580.3

1.56 × 10−4

cg13866093

6

28502727

UTR3

0.05

1.14 (1.09–1.20)

2.09 × 10−7

rs7767188

1571.0

3.26 × 10−5

cg24388424

6

28565403

Intronic

0.01

0.78 (0.71–0.86)

3.31 × 10−7

rs7767188

1508.4

1.08 × 10−5

cg00444740

8

129162178

Upstream

0.02

1.21 (1.13–1.30)

1.55 × 10−7

rs7837688

622.8

1.01 × 10−3

cg06836406

9

130461544

Intergenic

0.02

0.79 (0.72−0.86)

3.55 × 10−7

rs1182

2114.5

1.74 × 10−7

cg20100049

11

67979188

Intronic

0.02

1.30 (1.22–1.39)

2.79 × 10−15

rs11228565

999.4

2.44 × 10−4

cg22370235

11

68451852

Upstream

0.02

1.29 (1.17–1.41)

1.50 × 10−7

rs11228565

526.7

0.37

cg04739953

11

68451858

Upstream

0.01

1.62 (1.41–1.87)

2.06 × 10−11

rs11228565

526.7

0.15

cg01715842

16

85045600

Upstream

0.47

1.05 (1.03–1.07)

2.95 × 10−7

rs199737822

2866.7

NA

cg13230424

17

45930033

Intronic

0.05

0.87 (0.82–0.91)

3.16 × 10−7

rs138213197

875.7

5.74 × 10−8

cg23397578

19

37742925

ncRNA_exonic

0.01

1.40 (1.24–1.57)

1.81 × 10−8

rs8102476

992.7

1.57 × 10−3

  1. NA not available. Bold values represent that these association p values remain largely unchanged after adjusting for risk SNP.
  2. aRisk SNPs identified in previous GWAS or fine-mapping studies.
  3. bR2: model prediction performance (R2) derived using FHS data.
  4. cOR (odds ratio) and CI (confidence interval) per one standard deviation increase in genetically predicted DNA methylation.
  5. dP value: derived from association analyses of 79,194 cases and 61,112 controls (two-sided); associations with P ≤ 6.47 × 10−7 based on Bonferroni correction of 77,243 tests (0.05/77,243) are shown.
  6. eUsing COJO method.
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