Fig. 2: Association between percentiles of 287-SNP polygenic risk scores (PRS) and breast cancer risk in combined Asian studies. | Nature Communications

Fig. 2: Association between percentiles of 287-SNP polygenic risk scores (PRS) and breast cancer risk in combined Asian studies.

From: European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

Fig. 2

The results for overall breast cancer, oestrogen-receptor (ER)-positive breast cancer and ER-negative breast cancer are shown in Fig. 2a–c, respectively. The squares/dots represent the odds ratios (ORs) and the vertical lines represent the corresponding 95% confidence intervals, with middle quintile (40–60th) as the reference category. Solid lines represent the observed ORs, black dashed lines represent the predicted ORs of PRSs under a multiplicative polygenic model in the Asian population and the red dashed line represent the predicted OR in the European population. The analysis was conducted using 15,755 cases and 16,438 controls. Of 15,755 cases, 9989 were ER-positive breast cancer while 4611 were ER-negative breast cancer. Source data are provided in Supplementary Table 5.

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