Table 2 Association between standardised polygenic risk scores and breast cancer risk.

From: European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

   

287-SNP PRS

287-SNP PRS

229-SNP PRS

229-SNP PRS

 

Cases, N

Controls, N

OR per SDa (95% CI)

AUC

OR per SDa (95% CI)

AUC

Asian studies in BCAC

      

Overall BC

15,755

16,483

1.52 (1.49–1.56)

0.613

1.49 (1.45–1.52)

0.611

ER-positive

10,477

16,483

1.62 (1.57–1.67)

0.627

  

ER-negative

4,764

16,483

1.41 (1.36–1.46)

0.594

  

Asians within North American Studies in BCAC

      

Overall BC

1507

1212

1.36 (1.25–1.49)

0.577

1.33 (1.22–1.45)

0.579

ER-positive

1022

1212

1.38 (1.25–1.53)

0.586

  

ER-negative

280

1212

1.49 (1.26–1.76)

0.587

  

Prospective cohort

      

Overall BC

413

9842

  

1.49 (1.33–1.67)

0.61

European studies

      

Overall BC

11,225

17,788

1.61 (1.57–1.66)

0.630

1.59 (1.55–1.64)

0.627

ER-positive

7809

17,788

1.68 (1.64–1.73)

0.642

  

ER-negative

1234

17,788

1.44 (1.36–1.53)

0.600

  
  1. aAdjusted for first ten principal components and study, and standardised to SDs of PRSs in European controls as shown in Table 1. For prospective cohort, model was adjusted for first seven principal components. Only 229 of the 287 SNPs that were polymorphic and could be imputed were available for the prospective cohort. To enable comparison between case-control studies and prospective cohort, we included the results of 229-SNP PRS for all studies. For studies in Breast Cancer Association Consortium (BCAC), AUCs were adjusted by study. The OR per SD and AUC for European studies were estimated using the same data on the prospective cohorts as described in Mavaddat et al.7. PRS polygenic risk scores.
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