Table 6 Association between Asian-specific PRSs and overall breast cancer risk.

From: European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

PRS

SNP selection

Number of SNPs published

Number of SNPs used in analyses

SD controls

OR per SD (95% CI)

AUC

Low et al.27

Identified in Asian

5

5

0.292

1.25 (1.23–1.27)

0.563

Lee et al.26

Identified in European/Asian

51

51

0.469

1.28 (1.26–1.30)

0.562

Wen et al.15

Identified in European/Asian

44

44

0.400

1.41 (1.39–1.44)

0.586

Hsieh et al.17

Identified in European/Asian

6

6

0.356

1.10 (1.08–1.11)

0.533

Chan et al.19

Identified in European/Asian

46

45a

0.983

1.21 (1.19–1.23)

0.558

Mavaddat et al.7

Identified in European

313

287

0.564b

1.51 (1.22–1.86)b

0.617b

  1. PRSs were constructed using per allele log odds ratios as reported in the literature. As Asian case–control studies genotyped by iCOGs array and 744 samples from MYBRCA batch 1 were used as part of the development studies in Wen et al. (2016), to avoid upward bias, we restricted these evaluation analyses to Asian cases–controls studies genotyped using the OncoArray and removed overlapping samples in MYBRCA batch 1.
  2. aOne SNP rs146699004 was not imputed and hence not included in the analyses.
  3. bAnalyses of 287-SNP PRS was repeated using the same dataset as described.
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