Fig. 5: Regional association plots for lead SNPs associated with anti-EBV IgG levels (p < 1 × 10−8), n = 4365 individuals. | Nature Communications

Fig. 5: Regional association plots for lead SNPs associated with anti-EBV IgG levels (p < 1 × 10−8), n = 4365 individuals.

From: Distinct genetic architectures and environmental factors associate with host response to the γ2-herpesvirus infections

Fig. 5: Regional association plots for lead SNPs associated with anti-EBV IgG levels (p < 1 × 10−8), n = 4365 individuals.

a Lead association on chromosome 6 in HLA-DQA1 with anti-EBNA-1 IgG (rs9272371, p = 3.60 × 10−44). b Secondary association on chromosome 6 in HLA-DRA with anti-EBNA-1 IgG (rs3129867, pcond = 2.78 × 10−11). c Lead association on chromosome 6 in the HLA-DQB1 with anti-VCA IgG (rs71542439, p = 1.15 × 10−12). GWAS performed using linear mixed model accounting for kinship in GEMMA. The lead SNPs are labelled and coloured in purple. LD (r2) was calculated based on SNP genotypes in PLINK.

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