Table 3 Loci with significant evidence of association with anti-EBV IgG levels (N = 4365).

From: Distinct genetic architectures and environmental factors associate with host response to the γ2-herpesvirus infections

Trait

Chr:Pos(b37)

Variant

Nearest genea

Consequencea

EA

EAF (%)

p

β (95% CI)

EBNA-1

6:32604654

rs9272371

HLA-DQA1

Intron

C

26.9

3.63 × 10−44

−0.37 (−0.43 to −0.31)

EBNA-1

6:32404220

rs3129867

HLA-DRA

Upstream

G

49.2

2.10 × 10−24*

−0.25 (−0.30 to −0.20)

VCA

6: 32630257

rs71542439

HLA-DQB1

Intron

T

21.1

1.15 × 10−12

−0.21 (−0.27 to −0.15)

  1. EA effect allele, EAF effect allele frequency.
  2. *pcond on lead SNP, β (95% CI) = 2.78 × 10−11, −0.15 (−0.18 to −0.11).
  3. aAnnotated using Ensembl VEP.
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