Fig. 5: Interaction of mito-specific C-terminal extension of EF-G1mt with rRNA and tRNA. | Nature Communications

Fig. 5: Interaction of mito-specific C-terminal extension of EF-G1mt with rRNA and tRNA.

From: Structures of the human mitochondrial ribosome bound to EF-G1 reveal distinct features of mitochondrial translation elongation

Fig. 5: Interaction of mito-specific C-terminal extension of EF-G1mt with rRNA and tRNA.The alternative text for this image may have been generated using AI.

a The C-terminal extension (CTE, green) of domain IV (red) interacts with the 16S LSU rRNA helix 71 (H71, blue). b Superposition of the A-site bound tRNAmt (purple) onto the EF-G1mt-bound human 55S structure revealed that while bulk of domain IV of EF-G1mt overlaps with the anticodon-stem-loop region, the CTE partially overlaps with the CCA arm of the A-site tRNAmt. Landmarks on thumbnails to the left, which depict the overall orientations of the 55S mitoribosome, are as in Fig. 4.

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