Fig. 5: Ybx1 is required for appropriate levels of PRC2 binding to chromatin.
From: Ybx1 fine-tunes PRC2 activities to control embryonic brain development
a Proportions of Ybx1-bound TSSs (categories 1–5 based on H3K27me3 and H3K4me3 distribution in Fig. 4) that overlapped CpG islands. b Percent of bivalent (co-occupied by H3K27me3 and H3K4me3) regions that overlap Ybx1-bound regions. c Ezh2/1 and Ybx1 CUT&RUN-seq tracks and H3K27me3 ChIP-seq at Foxg1, Neurod2, and Satb2 gene loci in Ybx1-KO and sibling control NPCs. d Heat maps of Ybx1 and Ezh2/1 distribution within 5 kb of Ybx1 CUT&RUN-seq peaks. e Heat maps of Ezh2/1, Ybx1, H3K27me3, and H3K4me3 within 5 kb of Ezh2/1 CUT&RUN-seq peaks.
