Fig. 6: Mechanistic underpinnings of the contribution of KIF3A SNPs rs11740584 and rs2299007 to skin barrier dysfunction. | Nature Communications

Fig. 6: Mechanistic underpinnings of the contribution of KIF3A SNPs rs11740584 and rs2299007 to skin barrier dysfunction.

From: Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk

Fig. 6

Allergic disease-associated KIF3A SNPs create new CpG sites, which are highly methylated in individuals carrying the alternate allele leading to decreased KIF3A expression. Decreased KIF3A results in increased TEWL due to defective cell-cell adhesion, and increased susceptibility to the development of AD. ALRG = allergen.

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