Fig. 7: Schematic representation of the findings. | Nature Communications

Fig. 7: Schematic representation of the findings.

From: Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates

Fig. 7: Schematic representation of the findings.

Schematic representation of the neurogenesis from different stages of NCCs via distinct trajectories for the neurons of the unmyelinated (nociceptive) versus myelinated (tactile mechanoreceptive and proprioceptive) lineages of our dataset. The genes predicted to be involved in the unfolding of the trajectories are represented at the starting point of the trajectories, while genes that define the latter stage of maturation in our dataset are represented on the endpoints of the trajectories. Note the distribution of some members of the PRDM family (putative histone methyltransferases) throughout the tree. From the trajectory leading to tactile mechanoreceptor and proprioceptive neurons, bursting of genes of competing genetic programs prior to binary fate decision during sensory neuron diversification is reported at the pre-bifurcation level. Those genetic programs direct towards either specific neuronal fate.

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