Fig. 3: Gram-scale reaction and functional group transformations. | Nature Communications

Fig. 3: Gram-scale reaction and functional group transformations.

From: Rhodium(II)-catalyzed multicomponent assembly of α,α,α-trisubstituted esters via formal insertion of O–C(sp3)–C(sp2) into C–C bonds

Fig. 3: Gram-scale reaction and functional group transformations.The alternative text for this image may have been generated using AI.

a Gram-scale reaction. b Functional group transformations. Reaction conditions: a3a (0.1 mmol), LiOH (2 equiv) in THF/H2O 4:1 (1 mL) at room temparature. b3a (0.1 mmol), K2CO3 (2 equiv) in MeOH (1 mL) at room temparature. c3a (0.1 mmol), NaBH4 (1.5 equiv) in MeOH (1 mL) at room temperature. d5a (0.1 mmol), PhNH2 (1.2 equiv) and TsOH (0.1 equiv) in toluene (1 mL) at 100 °C.

Back to article page