Fig. 6: MYC loss induces expression of HECTD4 and MYCBP2.
From: Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer
a mRNA expression of HECTD4, MYCBP2 in LNCaP cells transfected with Control or MYC targeting siRNA (2 days) followed by treatment with Vehicle or 20 μM ENZA (2 days). b mRNA expression of HECTD4, MYCBP2 and TRIM49 in PC3 cells transfected with Control or MYC targeting siRNA for 2 days. c MYC ChIP followed by qPCR in LNCaP cells at the promoters of the indicated genes. d MYC ChIP-seq plots in LNCaP cells (GSE73994) at the indicated genes. Statistical tests: p value determined by two-tailed t test (a, b). Error bars represent S.E.M. n = 3 independent experiments (a–c). **p < 0.01; ***p < 0.001.
