Fig. 7: Proposed model of Taf14 as an organization hub to orchestrate transcription machinery recruitment. | Nature Communications

Fig. 7: Proposed model of Taf14 as an organization hub to orchestrate transcription machinery recruitment.

From: Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation

Fig. 7

Taf14ET alone and Taf14ET-complexes undergo LLPS in vitro. Taf14 also contains an N-terminal YEATS domain recognizing acetylated and crotonylated histones. The existence of multiple Taf14ET-binding motifs, multiple histone and DNA-binding modules in the complexes, as well as various modifications on chromatins can increase binding multivalence between Taf14-containing complexes and chromatins. These Taf14-mediated interactions consequently promote phase separation of condensates in which different transcriptional machinery is concentrated, thereby ensuring efficient transcription.

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