Fig. 2: Time window for STDP at P13–21 and P35–42.
From: Astrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development
A post‐before‐pre pairing protocol at P13–21 (black) induces t‐LTD for Δt = −18 ms (n = 6) a, −25 ms (n = 6) c and −35 ms (n = 7) e but not for −50 ms (n = 6) or a more negative Δt. g At P35–42 (red), the same protocol induces t-LTP for Δt = −18 ms (n = 6) b, −25 ms (n = 6) d and −35 ms (n = 5) f but not for −50 ms (n = 6) or a more negative Δt. h Δt: time interval between EPSP onset and peak of postsynaptic spike. The EPSP slopes monitored before and after the pairing protocol are shown. Traces show eEPSPs before (1) and 30 min after (2) the pairing protocol. Scale bars: 5 mV, 50 ms. i Summary plot showing the time window for STDP at P13–21 (black triangles) and P35–42 (red triangles). **p < 0.01; ***p < 0.001, two-sided Student’s t test. The error bars represent the S.E.M. Source data are provided as a Source Data file.
