Fig. 3: Predicted MAb362 structural epitope. | Nature Communications

Fig. 3: Predicted MAb362 structural epitope.

From: A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction

Fig. 3: Predicted MAb362 structural epitope.The alternative text for this image may have been generated using AI.

a Superposition of the space filling molecular model of MAb362 (green) complex on the crystal structure of the complex of ACE2 (orange) -SARS-CoV-2 RBD (violet) (6VW123) two views are rotated 180°. b The binding interface on SARS-CoV-2 RBD with ACE2 calculated from the co-crystal structure of the complex. The binding interface shown as darker shade is defined as having vdW contacts great than−0.5 kcal mol−1. c Positioning of MAb362 on SARS-CoV-2 RBD (violet) relative to the binding of other currently published SARS-CoV-2 RBD-neutralizing antibodies: CR3022 (PDB: 6W4146; orange); S309 (PDB: 6WPT16; cyan); REGN10933 and REGN10987 (PDB: 6XDG25; magenta and yellow); P2B-2F6 (PDB: 7BWJ26; salmon); CB6 (PDB: 7C0127; wheat) and B38 (PDB: 7BZ528; blue). MAb362 recognized a unique epitope overlapping with the binding interface of ACE2. d Predicted MAb362 molecular model on the spike trimer in open conformation with one RBD domain exposed 6VYB45.

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